Paracetamol Instant Granules

Paracetamol（=Acetaminophen）Instant Granules（250mgor500mg） 1.Formulations No.1No.2 I.Paracetamol,finepowder...............................50g50g Sucrose,finepowder....................................128g– Sorbito lInstant（Merck）........................................–130g KollidonCL-M[1]...........................................90g50g Aspartame.......................................................7g7g Orangeflavour.................................................5g5g Strawberryflavour............................................5g5g Sodiumcitrate....................................................–3g Citricacid...........................................................–3g II.Kollidon30[1]................................................12g– Kollidon90F[1]..................................................–8g Ethanol96%..................................................75g50g 2.Manufacturing（Wetgranulation） GranulatemixtureIwithsolutionII,andpass througha0.8mmsieve. FormulationNo.1:Fill1.5gor3.0ginsachets. FormulationNo.2:Fill1.3gor2.6ginsachets. 3.Propertiesofthegranules Thefreeflowinggranulesareverywelldispersibleincoldwater. 4.Administration FormulationNo.1:Suspend 1.5gor3.0gofthegranules（=250mgor 500mgparacetamol）inaglassofwater. FormulationNo.2:Suspend 1.3gor2.6gofthegranules（=250mgor 500mgparacetamol）inaglassofwater.5. Properties of the suspensionsYellowish, milky appearance with a sweet and fruity taste. No sedimentationwithin two hours.6. Chemical stability of the granules （Formulation No. 1）No loss of paracetamol after 2 months at 60 C.