Paracetamol（=Acetaminophen）Tablet Cores （500mg） 1.Formulation I.Paracetamol,powder（RPR）.....................500g Dicalciumphosphate[9]............................30g KollidonCL[1]...........................................12g KollidonVA64[1]......................................20g
II.Kollidon90F[1]........................................10g Ethanol96%.....................................max.70g III.KollidonCL[1]...........................................12g Polyethyleneglycol,powder[6]..................10g 2.Manufacturing（Wetgranulation） GranulatemixtureIwithsolutionII,dry,sieveandmixwithIII.Presswith highcompressionforceof25–30kN. 3.Tabletproperties Weight.................................................587mg Diameter...............................................11mm Form..................................................biconvex Hardness................................................157N Disintegration.......................................<1min Friability................................................<0.1% Dissolution,10min....................................88% 30min...................................97%
关键字：paracetamol tablet cores
