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CharcoalTabletsII (250mg) 1.Formulation I.Activatedcharcoal..................................250g (Carbomedicinalis,Merck) Bolusalba(Merck)...................................150g II.Kollidon25[1]...........................................28g Acaciagum...............................................38g Water isopropanol(10 3)...................575ml III.CremophorEL[1]......................................15g Isopropanol...........................................300ml 2.Manufacturing(Wetgranulation) GranulatemixtureIwithsolutionII,pass througha1mmsieve,dryuntil therelativepowderhumidityof90%isreached,addsolutionIIIandpass againthroughasieve.Drythegranulesandpresswithlowcompression force.Drytheobtainedtablets. 3.Tabletproperties Weight.................................................481mg Diameter...............................................12mm Form...................................................biplanar Hardness..................................................55N Disintegration..........................................1min
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