Paracetamol（=Acetaminophen）Tablets
（500mg）
1.Formulations
No.1No.2
Paracetamol,crystalline...............................500g500g （Synopharm）
AvicelpH102[5]..........................................137g150g KollidonVA64[1]...........................................35g20g KollidonCL[1]...............................................21g15g Magnesiumstearate[2]....................................3g–
Polyethyleneglycol6000,powder[6]...................–15g Aerosil200[4].................................................4g2g 2.Manufacturing（Directcompression）
pass thelubricantthrougha200μmsieve,mixallothercomponents,
pass througha0.8mmsieve,addthelubricantandpresswithhigh
compressionforceof25–30kN.
3.Tabletproperties
No.1No.2
Weight..........................................699mg703mg Diameter...........................................12mml2mm
Form..........................................biplanarbiplanar
Hardness..............................................60N87N
Disintegration.............................................6min1min
Friability.............................................0.7%0.4%
Dissolution,10min........................................84%73%
30min........................................98%86%
关键字：paracetamol acetaminophen tablets
