SulfadiazinTablets
（450mg）
1.Formulation
I.Sulfadiazin...........................................465.0g Lacto semonohydrateD20[8]................93.0g
II.Kollidon30[1]........................................14.0g Water...................................................200.0g III.KollidonCL[1]........................................23.4g Talc[10]...................................................1.8g Aerosil200[4]..........................................0.2g Calciumarachinate[2]..............................0.2g 2.Manufacturing（Wetgranulation）
GranulatemixtureIwithsolutionII,dry,pass througha0.8mmsieve,
addmixtureIIIandpresswithlowcompressionforce.
3.Tabletproperties
Weight.................................................602mg Diameter...............................................12mm
Form...................................................biplanar
Hardness................................................152N
Disintegration..........................................3min
Friability................................................<0.1%
Dissolution,10min....................................77%
20min...................................87%
30min...................................89%
关键字：sulfadiazin tablets
