Multivitamin Tablets with Beta Carotene

MultivitaminTabletswithBetaCarotene
（1–2RDAofVitamins）
1.Formulations
No.1No.2
BetaCarotenedrypowder10%Betavit.....10.0g–
（BASF）.................................................................
BetaCarotenedrypowder10%..........................–70.0g Pharma（BASF）
Thiaminemononitrate（BASF）.........................2.0g2.2g Riboflavin（BASF）...........................................2.0g2.2g Nicotinamide...............................................16.0g6.5g CalciumD-panto thenate（BASF）...................11.0g11.5g Pyridoxinehydrochloride（BASF）....................2.0g2.2g Cyanocobalamin0.1%drypowder.................6.0g6.0g Ascorbicacid,powder（BASF）......................85.0g85.0g VitaminEacetatedrypowderSD50............31.0g32.0g （BASF）
Ludipress[1].............................................321.0g210.0g KollidonVA64[1]................................................–7.0g Magnesiumstearate[2].................................3.0g3.0g Orangeflavour..............................................7.0g7.0g Saccharinsodium.........................................2.0g2.5g 2.Manufacturing（Directcompression）
Mixallcomponents,pass througha0.8mmsieve,mixandpresswith
mediumcompressionforce.
3. Tablet properties
No. 1 No. 2
Weight ..........................................508 mg 449 mg
Diameter ...........................................12 mm 12 mm
Form ..........................................biplanar biplanar
Hardness ..............................................72 N 47 N
Disintegration （water） ....................................5 min 10 min
Friability ...........................................< 0.1% 0.15%
4. Chemical stability of vitamins in formulation No. 1 （20–25 C, HPLC）
Sto rage time Beta Carotene B1 B2 B5 B6 C
6 Months 100% 100% 90% 100% 98% 96%
12 Months 100% 98% 87% 100% 97% 94%
5. Remark
Formulation No. 1 could be commercialized in Europe as dietary food
because all components are allowed for this application.