Paracetamol(=Acetaminophen) Caffeine
Tablet
(500mg 60mg)
a)Formulationofthegranules
Acetaminophenpowder.........................500.0g Caffeinepowder......................................60.0g KollidonVA64(30%)............................28.8g b)Manufactureofthegranules
TheactiveingredientsandthedissolvedKollidonVA64weregranulated
inanStephan-Mixer.Thanthegranulateispass edthroughan
800μmsieveanddriedfor24hours.
Processparameters
Mixingtime..............................................3min
Rotations............................................600/min
c)Formulationofthetablets
Acetaminophenpowder......................500.0mg Caffeinepowder...................................60.0mg KollidonVA64...................................28.8mg KollidonCL........................................19.5mg Aerosil200.............................................7.0mg Magnesiumstearate[8]...........................7.0mg d)Tableting Thegranuleswerepass edto getherwithmagnesiumstearate,
Aerosil200andKollidonCLthroughan800μmsieve,blended
for10mininaTurbulamixerandcompressedinto tabletswithaforce
ofabout8kN.
Tabletpress..................KorschpH106,30rpm
Compressionforce..................................8.0kN
e) Tablet properties
Weight ...............................................630.9mg
S rel ........................................................0.7%
Diameter ................................................12mm
Form ...................................................biplanar
Hardness...................................................71N
Friability.................................................0,75%
关键字:paracetamol acetaminophen caffeine