AcetylsalicylicAcid Paracetamol （=Acetaminophen） CaffeineTablets （250mg 250mg 50mg） 1.Formulation I.Acetylsalicylicacid,crystalline（Merck）......250g Paracetamol,crystalline（Merck）...............250g Caffeine（BASF）.........................................50g
II.Kollidon90F[1]........................................50g Isopropanol...............................................q.s. III.Magnesiumstearate[2]...............................5g KollidonCL[1]...........................................16g 2.Manufacturing（Wetgranulation） GranulatemixtureIwithsolutionII,dryandsievethrougha0.8mm screen,addthecomponentsIIIandpresswithhighcompressionforce. 3.Tabletproperties Weight.................................................670mg Form...................................................biplanar Diameter...............................................12mm Hardness..................................................45N Disintegration..........................................6min Friability...................................................0.7% 4.Physicalstability（12months,20–25C） Weight.................................................670mg Hardness..................................................65N Disintegration..........................................4min Friability...................................................0.9%
关键字：acetylsalicylic acid paracetamol
