Nalidixic Acid Tablets

NalidixicAcidTablets （500mg） 1.Formulation I.Nalidixicacid...........................................500g II.Kollidon30[1]...........................................15g Water......................................................125g III.KollidonCL[1]..........................................25g Magnesiumstearate[2]...............................5g 2.Manufacturing（Wetgranulation） GranulateIwiththesolutionII,dryandpass througha0.8mm-sieve, addthemixtureIII,mixduring10minutes,pass againthrougha0.8mmsieve andpresswithlowcompressionforce（10kN）. 3.Tabletproperties Weight.................................................545mg Diameter...............................................12mm Form...................................................biplanar Hardness................................................104N Disintegration（water）...............................1min Friability...................................................0.4% Dissolution（30min）...................................59% （60min）...................................73%