Paracetamol（=Acetaminophen） Doxylamine CaffeineEffervescent Granules（500mg 5mg 33mg/2.1g） 1.Formulation I.Paracetamol,powder...............................500g Doxylaminesuccinate..................................5g Caffeine（BASF）.........................................33g Tartaricacid............................................391g Sodiumhydrogencarbonate....................417g
II.Kollidon30[1].............................................6g Isopropanol（orEthanol）..............................q.s. III.Sodiumcitrate...........................................30g Sugar.....................................................707g 2.Manufacturing GranulatemixtureIwithsolutionII,dryat60Cundervacuumconditions, sieveandmixwithIII. Fill2.1ginsachetsatmaximum30%ofrelativeatmospherichumidity. 3.Properties Freeflowinggranules. 4.Remark Ifthesolventinsopropanolisreplacedbywaterthegranulationshould bedoneinafluidizedbed.
关键字：paracetamol doxylamine caffeine
