Paracetamol（=Acetaminophen）–
Taste-maskedCrystals
a）Formulation
Theformulationisdesignedfor500gofacetaminophengranules[1].
Polymersuspension
KollicoatSR30D[1]...........................73.33g b）Preparationofthespraysuspension
Thedispersionisuseddirectlywithoutanyadditives.
c）Coating ThecrystalswerecoatedinanAeromaticStrea-1（AeromaticAG）.The
dispersionwassprayedcontinuouslyonto thefluidized,pre-heated
crystalsfromtheto p.
Processparameters
Inletairtemperature.................................60C
Outletairtemperature...............................40C
Producttemperature................................41C
Airflow................................................80m3/h
Nozzlediameter.....................................0.8mm
Sprayingrate............................approx.9g/min
Sprayingtime..........................................9min
Ato mizingpressure.................................1.0bar
Drying............................................45C/5min
Coatingweight...........................................4%
Crystallineacetaminopheniscoatedwith4%KollicoatSR30D.
关键字：paracetamol taste masked
