Paracetamol Norephedrine Phenyltoloxamine Tablets

Paracetamol（=Acetaminophen） Norephedrine Phenylto loxamineTablets （300mg 25mg 22mg） 1.Formulation I.Paracetamol,crystalline（BASF）................300g Norephedrinehydrochloride（BASF）............25g Phenylto loxamine......................................22g Cornstarch[3]........................................200g II.Kollidon30[1]...........................................25g Ethanol96%..............................................q.s. III.KollidonCL[1]..........................................25g Magnesiumstearate[2]...............................5g 2.Manufacturing（Wetformulation） GranulatemixtureIwithsolutionII,dry,pass througha0.8mmsieve, addIIIandpresswithhighcompressionforce. 3.Tabletproperties Weight.................................................601mg Diameter...............................................12mm Form...................................................biplanar Hardness..................................................97N Disintegration......................................1–2min Friability...................................................0.7%