Paracetamol（=Acetaminophen） Caffeine
ASSTablets
（250mg 60mg 250）mg a）Formulationofthegranules
Acetaminophenpowder.........................250.0g Caffeinepowder......................................50.0g ASSpowder..........................................250.0g KollidonVA64.....................................60.0g b）ManufacturebyRollerCompaction
TheactiveingredientsandKollidonVA64weregranulatedinanGerteis
Rollercompakto r.
Processparameters
Force................................................5.0kN/cm
Crack....................................................2.9mm
Looser..................................................5.0rpm
Dosingsrew........................................90.5rpm
Plugscrew........................................108.6rpm
Granulato r..............................................50rpm
c）Formulationofthetablets
Acetaminophenpowder......................250.0mg Caffeinepowder...................................50.0mg ASSpowder.......................................250.0mg KollidonVA64...................................60.0mg KollidonCL........................................20.0mg Aerosil200.............................................3.0mg Magnesiumstearate[8]...........................4.0mg
d） Tableting
The granules were pass ed to gether with magnesium stearate,
Aerosil 200 and Kollidon CL through an 800μm sieve, blended
for 10 min in a Turbula mixer and compressed into tablets with a force
of about 12kN.
Tablet press ..................Korsch pH106, 30 rpm
Compression force ................................11.5kN
e） Tablet properties
Weight ...............................................629.7mg
S rel ........................................................1.4%
Diameter ................................................12mm
Form ...................................................biplanar
Hardness...................................................72N
Friability.................................................2,75%
关键字：paracetamol acetaminophen caffeine
