Paracetamol（=Acetaminophen） Caffeine Tablets
（500mg 50mg）
1.Formulation
Paracetamol,crystalline（BASF）................500g Caffeine（BASF）.........................................50g AvicelpH101[5].......................................90g Kollidon30[1]...........................................10g KollidonCL[2]..........................................20g Polyethyleneglycol6000,powder[6]..........10g 2.Manufacturing（Directcompression）
Mixallcomponents,pass throughasieveof0.8mmandpresswithhigh
compressionforce.
3.Tabletproperties
Weight.................................................683mg Diameter...............................................12mm
Form...................................................biplanar
Hardness..................................................56N
Disintegration.......................................<1min
Friability...................................................0.9%
Dissolution,15min....................................91%
4.Remark
Iftheflowabilityofthepowdermixturefortablettingisnothighenough
someAerosil200[4]shouldbeadded.
关键字：paracetamol acetaminophen caffeine
