FusidicAcidTabletCores (125mg) 1.Formulation I.Fusidicacid,sodiumsalt.......................125.0g Dicalciumphosphate,DI-TAB[9].............63.0g
II.Kollidon90F[1].......................................2.5g Isopropanol.............................................30ml III.KollidonCL[1].........................................6.2g Aerosil200[4]..........................................1.3g Magnesiumstearate[2].............................3.0g 2.Manufacturing(Wetgranulation) GranulatemixtureIwithsolutionII,dry,pass througha0.8mmsieve, addthemixtureIIIandpresswithlowcompressionforce. 3.Tabletproperties Weight.................................................200mg Diameter.................................................9mm Form..................................................biconvex Hardness..................................................55N Disintegration........................................25min Friability.....................................................0% 4.Remark to acceleratethedisintegrationtheamounto fKollidon90Fshouldbe reducedandKollidonCLshouldbeappliedinintra-andextragranular form.
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