Garlic Tablets Cores

GarlicTabletsCores （100mg） 1.Formulation I.Calciumphosphate,dibasic[9]..................95g Lacto semonohydrate[8]...........................94g II.Kollidon30[1].............................................9g Water........................................................25g III.Driedgarlicpowder.................................100g Magnesiumstearate[2]...............................2g 2.Manufacturing（Wetgranulation） GranulatemixtureIwithsolutionII,pass througha0.8mmsieve,addIII andpresswithlowcompressionforce. 3.Tabletproperties Weight.................................................312mg Diameter.................................................9mm Form..................................................biconvex Hardness..................................................98N Disintegration........................................23min Friability...................................................0.3% 4.Remark ThesetabletscouldbecommercializedinEuropeasdietaryfood becauseallcomponentsareallowedforthisapplication.5. Masking of the garlic smellto mask the smell of the tablets the following coating formulation could beapplied:I. Kollicoat MAE 30DP ...............................50.0%Triacetin ..................................................2.2%Water ....................................................25.0% II. Sicovit Iron Oxide Red..............................0.5%Sicovit Titanium Dioxide ...........................0.5%Vanilline .....................................................q.s.Talc .........................................................4.0%Water.....................................................17.8%Prepare the two suspensions separately, mix, pass through a colloid mill andspray onto the tablet cores in a perforated coating pan （e.g. Accela Cota 24inch） until a weight gain of 8 - 10 % of the cores ist obtained.Spray conditions:Inlet temperature ...........................................55-60COutlet temperature.........................................32-34CSpray rate ..............................................38-40 ml/minPan speed..............................................about 11 rpmAto mizing air pressure .......................................45 psiSpray time ............................................about 100 min