DimenhydrinateTabletCores (100mg) 1.Formulation I.Dimenhydrinate.......................................100g Lacto semonohydrate[8]...........................40g Cornstarch[3]..........................................40g Kollidon90F[1]..........................................6g
II.Isopropanol...............................................30g III.KollidonCL[1]...........................................14g Talc[10]....................................................16g Aerosil200[4].............................................2g Calciumarachinate[2].................................2g 2.Manufacturing(Wetgranulation) GranulatemixtureIwithsolutionII,dry,pass througha0.8mmsieve, mixwithIIIandpresswithlowcompressionforce. 3.Tabletproperties Weight.................................................210mg Diameter.................................................9mm Form..................................................biconvex Hardness.................................................27N Disintegration.......................................<1min Friability......................................................1%
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