AmbroxolHClSustained-ReleasePellets ReleasingTablets（MUPS-Formulation）
d）Formulation
Theformulationisdesignedfor500goftablets:
AmbroxolHCl/KollicoatSR30Dpellets*...250.0g Microcrystallinecellulose
Vivapur200[7]........................................250.0g Magnesiumstearate[8]..................................2.5g e）Procedure
Mixtheingredientsto gether,pass througha0.8mmsieveandcompress
into tabletswithaforceofabout15kN.
Tabletpress................KorschEK0,30tablets/min
Compressionforce........................................15kN
f）Tabletproperties
Weight.......................................................400mg Diameter.....................................................10mm
Form........................................................biplanar
Hardness.................................................92-116N
*
关键字： 释放
