Tretinoin Solution

TretinoinSolution （50mg/100g） 1.Formulation I.Tretinoin（BASF）......................................0.05g CremophorRH40[1]..............................14.0g Propyleneglycol[1].................................15,0g Butylhydroxyto luene...............................0.05g AlphaBisabololnat.（BASF）.......................0.1g II.Water.....................................................70.0g Parabenes/sorbicacid................................q.s. 2.Manufacturing HeatmixtureIto 40–50Cto obtainaclearSolution .Introducethis warmSolution slowlyinSolution II.ItformsaclearyellowSolution . 3.PropertiesoftheSolution Clearyellowliquid. 4.Chemicalstability（20–25C,protectedfromlight） MonthsTretinoincontent 00.046%=100% 30.046% 60.044% 90.045% 120.044%=96% 5.Remark Itisveryimportantto protectthisformulationfromlightto avoidthe isomerizationanddegradationoftretinoin.