Propanidide Injectable Solution

PropanidideInjectable Solution （50mg/ml） 1.Formulation I.Propanidide.............................................5.0g CremophorEL[1]...................................20.0g II.Preservatives.............................................q.s. WaterforInjectable s..........................ad100ml 2.Manufacturing MixpropanididewiththewarmCremophorEL（60C）andaddslowly thewarmSolution II.Thesterilisationcanbedonebyfiltrationorheat. 3.PropertiesoftheSolution AclearcolourlessSolution wasobtained. 4.Remarks –to reducetheviscosityandthesideeffects,CremophorELcouldbe substitutedbySoluto lHS15[1]. –InGermanyCremophorELmustbedeclaredonthepackageof Injectable s. –Duringtheheatsterilisationaseparationoftwolayerscanbeobserved. Shakingoftheampoulesduringcoolinggiveshomogeneous clearSolution s.