CarbamazepineOralSuspension
（2%=100mg/5ml）
1.Formulation
Carbamazepine（Flavine）...........................2.0g 1,2-Propyleneglycol[1]..........................20.0g Kollidon90F[1]........................................3.0g Saccharinesodium...................................0.1g Sodiumcitrate..........................................1.0g Sorbito l,crystalline.................................25.0g KollidonCL-M[1]......................................7.0g Water.....................................................41.9g 2.Manufacturing Stirrthemixtureofcarbamazepineandpropyleneglycolatleastduring 2hours,addKollidon90F,saccharine,sodiumcitrateandthewaterand
stirragainuntilthesecomponentsaredissolved.Dissolvesorbito linthis
mixtureandaddKollidonCL-Mto thewellstirredsuspensionto obtaina
homogeneoussuspension.
3.Propertiesofthesuspension
After1dayAfter1month（RT）
Colour:.............................................MilkywhiteMilkywhite
Relativesedimentationvolume..................100%98%
Redispersibility................................NotneededVeryeasy
Structureofthesediment.......Veryfineparticles,Veryfineparticles,
..................................................nocrystalsnocrystals
Viscosity..............................................VerylowVerylow
关键字：carbamazepine oral suension
