AciclovirOralSuspension
（2%=200mg/10ml）
1.Formulation
Aciclovir...................................................2.0g KollidonCL-M[1].....................................6.0g Kollidon30[1]..........................................3.0g Sorbito l[10]...........................................28.0g Citricacid................................................0.5g Preservative...............................................q.s.
Water.....................................................60.5g 2.Manufacturing Suspend aciclovirandKollidonCL-Minthesolutionoftheothercomponents
undervigorousstirring.
3.Propertiesofthesolution
Colour.....................................................white
Relativesedimentvolumeafter14days......96%
Redispersibilityafter14days......................easy
4.Remarks
–ThesubstitutionofKollidon30byKollidon90Fgivesamorecompact
sediment.
–Thedeletionofcitricacidgivesamuchmorecompactsediment.
–Thesubstitutionofcitricacidbysodiumcitrateimpairsstronglythe
redispersibility.
关键字：aciclovir oral suension
