Aluminium Hydroxide Magnesium carbonate/oxide Simethicone Tablets

AluminiumHydroxide Magnesium carbonate/oxide SimethiconeTablets （150mg 250mg 90mg） 1.Formulation I.Sucrose..................................................576g Aluminiumhydroxide................................157g Magnesiumcarbonate.............................160g Magnesiumoxide......................................97g Kollidon90F[1]........................................45g Aerosil200[4]...........................................22g II.Simethicone,suspension30%.................300g III.Menthol......................................................9g Saccharinsodium........................................1g Talc[10]....................................................49g Magnesiumstearate[2]..............................13g 2.Manufacturing（Wetgranulation） GranulatemixtureIwiththesimethiconesuspensionII,dry,sieve througha0.8mmscreen,addIIIandpresswithhighcompressionforce. 3.Propertiesofthetabletspressedwithtwodifferentdiameters 12mm20mm Weight....................................................1200mg1295mg Form........................................................biplanarbiplanar Hardness.....................................................130N55N Disintegration.............................................30min7min Friability........................................................0.1%0.7%