AluminiumHydroxide Magnesium
Hydroxide SimethiconeSuspension
(8% 8% 0.8%)
1.Formulation
I.Simethicone30%.....................................2.7g CremophorRH40[1]...............................3.0g Water.......................................................7.0g
II.Aluminiumhydroxidedrygel(Giulini)..........8.0g Magnesiumhydroxide...............................8.0g KollidonCL-M[1]...............................8–10.0g Sorbito l,crystalline[10]...........................10.0g Bananaflavour.........................................0.4g Coconutflavour........................................0.5g Saccharinsodium.....................................0.1g Water................................................ad100ml
III.Citricacid............................q.s.to adustpH9
2.Manufacturing I.MixCremophorRH40withsimethicone,heatto about50Cstirring wellandaddthewarmwater.
II.Dissolvetheflavoursandsaccharininwaterandsuspendaluminium
hydroxide,magnesiumhydroxideandKollidonCL-M.
III.AddemulsionIto thestirredsuspensionIIandadjust thepHto
about9withcitricacidifneeded.
3.Propertiesofthesuspension
Colour:..............................................................White
Aspect:.......................................Homogeneous,milky
Relativesedimentvolume(1day):.........................99%
关键字:aluminium hydroxide magnesium