Oxytetracycline SustainedRelease
Injectable fori.m.Veterinary
Application（2.2g/10ml）
（Accordingto US-Patent4.018.889（1976）
1.Formulation
Oxytetracycline .....................................22.65g Magnesiumoxide...................................1.92g SoluphorP[1]......................................40.00g Kollidon17PF[1]...................................5.00g Sodiumformaldehydesulfoxylate............0.44g 2-Aminoethanol......................................3.84g WaterofInjectable s................q.s.ad100.00ml
2.Manufacturing MixthewaterandtheSoluphorP,anddissolvetheKollidon17PFinthe
mixture.Heatthesolutionto 75C.Addthesodiumformaldehyde
sulfoxylateandstiruntildissolved.Afterthemagnesiumoxidehasbeen
suspended,slowlystirintheOxytetracycline untilaclearsolutionis
obtained.Afterthesolutionhascooled,setto pH8.5withaminoethanol.
3.Remarks
ThequalityoftheOxytetracycline andthecompleteabsenceofoxygen
duringthemanufacturingandpackagingofthesolutionisessentialto
obtainaacceptablechemicalstabilityandnodarkcolour.
Thereducingagente.g.sodiumformaldehydesulfoxylate（Rongalite?C,
BASF）mustbeselectedinaccordancewiththelegislationofthecorresponding country.
关键字：oxytetracycline sustained release
