SustainedReleaseCoatingofTheophylline
Pellets
1.Formulation
IPolymerSuspension:
KollicoatSR30D[1].............................223.7g 1,2-Propyleneglycol[1]..........................6.7g Water.................................................149.9g IIPigmentSuspension:
Kollidon30[1]........................................2.2g SicovitIronoxideRed30[1]....................2.2g SicovitTitaniumdioxide[1]......................2.2g Talc[10]...............................................15.7g Water...................................................44.7g to talI II:............................................447.3g IIITheophyllinepelletsSperofillin（BASF）
2.Manufacturingofthesuspension
IMixpropyleneqlycolwithwaterandsuspendslowlyKollicoatSR30D.
IIDissolveKollidon30inwater,suspendtheironoxideandtitaniom
dioxidepigmentsandtalcandhomogenizeinacolloidmill.
AddthepigmentsuspensionIIto thewellstirredpolymersuspensionI.
Stirtheobtainedsuspensionduringtheentirecoatingprocess.
3. Coating procedure （Fluidized bed Aeromatic Strea-1）
Loading of Sperofillin pellets ......................................................500 g
Quantity of spray suspension applied ............448 g = 2 mg solids/cm2
...................................................................224 g = 1 mg solids/cm2
Nozzle ...................................................................................0.8 mm
Spraying pressure ......................................................................1 bar
Inlet air .................................................................................80 m3/h
Inlet temperature.......................................................................60 C
Pellet temperature.....................................................................38 C
Outlet temperature ....................................................................37 C
Spray rate .........................................................................11.5 g/min
Spray time for 448 g suspension ..............................................39 min
Drying time after coating （45 C）.................................................5 min
关键字：sustained release coating
