SustainedReleaseCoatingof
CaffeinePellets
1.Formulationofthecoatingsuspension
IPolymerSuspension:
KollicoatSR30D[1].............................200.0g 1,2-Propyleneglycol[1]..........................3.3g Water.................................................100.0g IIPigmentsuspension:
Kollidon30[1]........................................2.1g Talc[10]...............................................14.5g SicovitironoxideRed[1].........................2.1g SicovitTitaniumdioxide[1]......................2.1g Water...................................................75.9g to talI II:............................................506.3g IIICaffeinespheronizedpellets10%.............500g 2.Manufacturingofthecoatingsuspension
IMixpropyleneglycolwithwaterandsuspendslowlyKollicoatSR30D.
IIDissolveKollidon30inwater,suspendthepigmentsandtalcand
homogenizeinacolloidmill.
AddthepigmentsuspensionIIto thewellstirredpolymersuspensionI.
Stirtheobtainedsuspensionduringtheentirecoatingprocess.
3. Coating procedure （Fluidized bed Aeromatic Strea-1）
Loading of caffeine pellets 10 % （III） ............................................500 g
Quantity of spray suspension applied ......................400 g = 3 mg/cm2
Nozzle ...................................................................................0.8 mm
Spraying pressure ......................................................................1 bar
Inlet temperature.......................................................................60 C
Outlet temperature ....................................................................35 C
Spray rate ..............................................................................3 g/min
Drying time after coating （45 C）.................................................5 min
关键字：sustained release coating
