ProtectiveFilmCoatingwithKollidonVA64
HydroxypropylCellulose
1.Formulations
No.1No.2
（Subcoating（Final
coating）
KollidonVA64[1]...........................................20g20g KlucelEF（Hercules）.....................................20g20g Talc....................................................................–20g SicovitIronoxide[1].......................................q.s.q.s.
Isopropanol..................................................760g–
Water.................................................................–740g 2.Manufacturingofthesuspension
DissolveKlucelandKollidonVA64inisopropanolorwaterandsuspend
thecolorantsandthetalc.Passthismixturethroughacolloidmill.
3.Coatingprocedure（Sugarcoatingpan）
No.1No.2
Loadingoftabletcores
（9mm,biconvex,surface3cm2）.....................2kg2kg Amounto fcoatingsuspension..................<800g800g Sprayphase.....................................................6s3s
Interval..........................................................0.5s0.5s
Dryingphase（warmair）....................................6s6s
Interval............................................................2s2s
Nozzle（WaltherWAXV）.............................0.8mm0.8mm
Quantityofsprayedsuspension/min..............25g6.8g Quantityofsolidsappliedoneach
tabletcore<3.2mg.......................................<1h3.1mg to talcoatingtime...........................................<1h5–6h
关键字：protective film coating
