EntericFilmCoatingofAcetylsalicylicAcid Crystals（Aqueous） 1.Formulations No.1No.2 I.Pigmentsuspension: Sicovittitaniumdioxide[1]...........................2.5g2.5g Talc[10]....................................................20.0g20.0g SicovitIronoxideRed[1].............................2.5g2.5g Water........................................................52.5g52.5g
II.Polymersuspension: KollicoatMAE30DP[1].............................250.0g– KollicoatMAE100P[1].......................................–75.0g Propyleneglycol[1]....................................11.2g11.2g Water......................................................161.3g326.3g to talI II:.......................................................500.0g500.0g 2.Manufacturingofthesuspension ISuspend thepigmentsandtalcinthewellstirredwaterandhomogenize inadiskmillorinacolloidmill. IISeparatelySuspend KollicoatMAE30DPinthemixtureofwaterand propyleneglycol（=No.1）orSuspend KollicoatMAE100Pinwater,stir 2-3hoursandaddthepropyleneglycol（=No.2） AddthepigmentsuspensionIto thewellstirredpolymersuspension
II. Stirtheobtainedsuspensionduringtheentirecoatingprocess.3. Coating procedure （Fluidized bed, Aeromatic Strea1）Acetylsalicylic acid crystals loading...................................500 gSize of the crystals .................................................0.3-1.0 mmQuantity of suspension applied.........................................500 gQuantity of solids applied per cm2 ..........................about 6 mgQuantity of film-forming agent applied per cm2 ........about 4 mgType of spraying ......................................................continuousSpraying pressure ............................................................1 barInlet air temperature.........................................................60 COutlet air temperature..................................................... 35 CSpraying time .............................................................. 100 min
关键字：enteric film coating
