SustainedReleaseCoatingof
AcetylsalicylicAcidCrystals
a）Formulation
Theformulationisdesignedfor800gofacetylicsalicylicacidcrystals
[12].
Spraysuspension
KollicoatSR30D[1]........................666.25g Talc[3]..................................................70.00g Water..................................................666.25g b）Preparationofthespraysuspension
Addtalkto thegivenamounto fwaterwithvigorousstirring.Thenadd
KollicoatSR30Dwithslowstirring.
c）Coating ThecrystalswerecoatedinaGlattGPCG1coater.Thesuspension
wassprayedcontinously onto thefluidized,pre-heatedcrystalsbythe
Wurstermethod.Weightgainsof5,10,15and20%weretested.
Processparameters
Machine.......................................GlattGPCG1
Method.........................Botto m-spray（Wurster）
Inletairtemperature...........................50–55C
Outletairtemperature........................29–32C
Producttemperature..........................35–40C
Airflow................................................90m3/h
Nozzlediameter.....................................1.2mm
Sprayingtime.......................................166min
Sprayingrate.........................approx.8.9g/min
Ato mizingpressure.................................1.2bar
Drying............................................40C/15min
Coatingweight.........................................20%
关键字：sustained release coating
