ProtectiveFilmCoatingwithKollidonVA64 Hypromellose 1.Formulation I.KollidonVA64[1]......................................53g LutrolE6000[1].........................................12g HPMC6mPas.........................................79g （e.g.Pharmacoat606,Shin-etsu） Water......................................................732g
II.SicovitTitaniumdioxide[1]........................36g SicovitIronoxideRed30[1].......................18g Talc[10]....................................................54g Water......................................................216g 1200g 2.Manufacturingofthesuspension DissolveLutrolE6000andKollidonVA64in732mlofwater,addHPMC andstirr45minavoidingtheformationofto omuchofairbubbles. Suspend thepigmentsandtalcin216mlofwaterandpass thismixture throughacolloidmill. to obtainthefinalcoatingsuspensionmixsolutionIwithsuspension
II. 3.Coatingprocedure（AccelaCota24） Tabletcoreloading.................................5.0kg Coresize..................................9mmbiconvex Amounto fcoatingsuspensionapplied.....1.2kg Inletairtemperature................................60C Outletairtemperature..............................40C Nozzle..................................................1.0mm Rotationspeedofthepan......................12rpm Sprayingpressure.................................2.0bar Sprayingrate......................................50g/min Sprayingtime（continuously）...................34min Finaldrying..............................................2min Dryingafterspraying...................5minat60C Quantityoffilmformerapplied.......3.14mg/cm2
关键字：protective film coating
