EntericFilmCoatingofSoftGelatinCapsules
（Aqueous,colourless）
1.Formulations
No.1No.2
KollicoatMAE30DP[1]...............................1,680g–
KollicoatMAE100P[1].........................................–504g Propyleneglycol[1]......................................101g101g Water...........................................................619g1,795g Total.........................................................2,400g2,400g 2.Manufacturingofthesuspension
No.1:DissolvethepropyleneglycolinthewaterandSuspend theKollicoat
MAEdispersioninthiswellstirredsolution.
No.2:Suspend KollicoatMAE100Pinwaterandstirfor2-3hoursuntil
ahomogeneousdispersionisobtained.Addthepropyleneglycol.
Stittheobtainedsuspensionduringtheentirecoatingprocess.
3.Coatingprocedure（AccelaCota24）
Softgelatincapsulesloading..............................................5kg Quantityofsuspensionapplied......................................2,400g Quantityofsolidsappliedpercm2..................................12mg Quantityoffilm-formingagentappliedpercm2................10mg Sprayingpressure............................................................2bar
Typeofspraying......................................................continuous
Inletairtemperature.........................................................50C
Temperatureofthecapsules......................................30-32C
Sprayingtime................................................................70min
Sprayingrate.........................................................30-35g/min
关键字：enteric film coating
