Enteric Film Coating of Pellets

EntericFilmCoatingofPellets（Aqueous） 1.Formulations No.1No.2 I.Pigmentsuspension: Sicovittitaniumdioxide[1]............................45g45g Talc[10].....................................................180g180g Kolidon30[1]..............................................23g23g Water.........................................................500g500g II.Polymersuspension: KollicoatMAE30DP[1].............................2,250g– KollicoatMAE100P[1].......................................–675g Propyleneglycol[1]......................................67g67g Water......................................................1,435g3,010g to talI II:.......................................................4,500g4,500g 2.Manufacturingofthesuspension ISuspend thepigmentsandtalcinthewellstirredsolutionofKollidon 30andhomogenizeinadiskmillorinacolloidmill. IISeparatelySuspend KollicoatMAE30DPinthemixtureofwaterand propyleneglycol（=No.1）orSuspend KollicoatMAE100Pinwater,stir 2-3hoursandaddthepropyleneglycol（=No.2） AddthepigmentsuspensionIto thewellstirredpolymersuspension II. Stirtheobtainedsuspensionduringtheentirecoatingprocess. 3.Coatingprocedure（HttlinKugelcoaterHKC5TJ） Pelletloading.....................................................................5kg Pelletsize...............................................................0.8-1.2mm Quantityofsuspensionapplied......................................4,500g Quantityofsolidsappliedpercm2....................................3mg Quantityoffilm-formingagentappliedpercm2.................2mg Typeofspraying......................................................continuous Inletairtemperature.........................................................60C Outletairtemperature................................................32-35C Sprayingtime..............................................................100min Sprayingrate..............................................................45g/min