Nifedipine Tablet Cores

NifedipineTabletCores （10mg） （Accordingto Ph.Eur.Patent0078.430,1982） 1.Formulation I.Nifedipine...............................................10.0g Kollidon25[1]........................................40.0g II.Methylenechloride................................180.0g III.MicrocrystallineCellulose[5]..................105.0g Cornstarch[3].......................................20.0g KollidonCL[1]........................................25.0g IV.Magnesiumstearate.................................0.4g 2.Manufacturing（Wetgranulation） DissolvemixtureIin II.GranulatemixtureIIIwithsolutionI/II,sieve,dry theobtainedcoprecipitate,addIVandpresswithlowto medium compressionforce. 3.Tabletproperties Weight.................................................223mg Diameter.................................................8mm Form..................................................biconvex Hardness................................................132N Disintegration...............................about10min Friability................................................<0.1% Dissolution（20min）...................................90%