Multivitamin Syrup, I

MultivitaminSyrup,I （1–2RDA/20ml） 1.Formulation I.VitaminApalmitate..............................10.0mg 1.7Mio.i.u./g（BASF）...................................... VitaminD40Mio.i.u./g........................0.05mg VitaminEacetate（BASF）....................100.0mg Butylhydroxyto luene..............................2.0mg CremophorRH40[1]...............................4.5g II.Water.....................................................10.0g III.Saccharose............................................45.0g Methylparabene................................200.0mg Citricacid............................................80.0mg IV.Glycerol...................................................9.6g Water.....................................................25.0g V.Thiaminehydrochloride（BASF）.............15.0mg Riboflavin5’-phosphatesodium............15.0mg Nicotinamide.......................................55.0mg Pyridoxinehydrochloride（BASF）...........15.0mg Ascorbicacid,crystalline（BASF）.........300.0mg Sorbicacid........................................100.0mg Propyleneglycol[1]..................................5.0g to talamount...........................................100g 2.Manufacturing HeatIandIIseparatelyto about60Candmixslowlywellstirringto obtainaclearsolution.DissolveIIIinthehotsolutionIVto obtainaclear solution.MixthecoolsolutionsI/II,III/IVandVandadjust thepHvalue to 4.0–4.2.Passduring10minnitrogen throughthesolutionandfillin flasksundernitrogen .3. Chemical stability （20–25 C; HPLC methods）（9 months） （12 months）Vitamin A 86% 73%Vitamin B1 88% 83%Vitamin B2 96% 92%Vitamin C 78% 77%