Mito nafideTablets (60mg) (accordingto A.I.to rresetal.,Pharm.ActaHelv.69,1994,101–105) 1.Formulation I.Mito nafide..............................................58.0g Lacto semonohydrate[8]........................21.3g Cornstarch[3].........................................8.7g
II.Kollidon30[1]..........................................2.5g Water..............................................about18g III.Cornstarch[3].........................................8.7g Magnesiumstearate[2].............................0.8g 2.Manufacturing(Wetgranulation) GranulatemixtureIwithsolutionII,dry,sieve,mixwithIIIandpressto tablets. 3.Tabletproperties Weight.................................................172mg Diameter.................................................7mm Form...................................................biplanar Hardness..................................................53N Disintegration..........................................9min Friability...................................................0.2% Dissolution(12min)...................................70%
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