MetforminTablets （500mg） 1.Formulation I.Metforminhydrochloride..........................500g Dicalciumphosphate,DI-TAB[9]..............100g Kollidon90F[1]........................................15g
II.Kollidon90F[1]..........................................8g Isopropanol...............................................90g III.KollidonCL[1]............................................5g Polyethyleneglycol6000,powder[6]..........15g 2.Manufacturing（Wetgranulation） GranulatethemixtureIwithsolutionII,mixwithIII,pass througha0.8mm sieveandpresswithmediumcompressionforce. 3.Tabletproperties Weight.................................................650mg Diameter...............................................12mm Form...................................................biplanar Hardness.............................................>200N Disintegration..........................................6min Friability...................................................0.3% 4.Remark Dueto thehighhardnesstheamounto fKollidon90Fcouldbereduced.
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