Hydrochlorothiazide Tablets

HydrochlorothiazideTablets （50mg）,Wg 1.Formulation I.Hydrochlorothiazide（Chemag）....................50g Lacto semonohydrate[8].........................422g Kollidon90F[1]..........................................8g II.2-Propanol..............................................38ml III.KollidonCL[1]...........................................15g Magnesiumstearate[2]...............................2g 2.Manufacturing（Wetgranulation） GranulatemixtureIwithsolutionII,pass througha0.8mmsieve,addIII andpresswithlowcompressionforce. 3.Tabletproperties Weight.................................................495mg Diameter...............................................12mm Form...................................................biplanar Hardness..................................................55N Disintegration........................................<1min Friability................................................<0.1% Dissolution（30min）...................................92% （60min）.................................100%