Alpha-Methyldopa Tablet Cores

Alpha-MethyldopaTabletCores （250mg）,Wg 1.Formulations No.1No.2 I.Alpha-Methyldopa........................................275g275g Lacto semonohydrate[8]................................55g– Calciumphosphate,dibasic[9]............................–55g II.Kollidon30[1]................................................15g15g Isopropanol..................................................80ml80ml III.KollidonCL[1].................................................8g8g Magnesiumstearate[2]....................................2g2g 2.Manufacturing（Wetgranulation） GranulatemixtureIwithsolutionII,pass throughasieve,mixthedry granuleswithIIIandpresswithmediumcompressionforce. 3.Tabletproperties No.1No.2 Weight......................................................361mg362mg Diameter....................................................11mml1mm Hardness.....................................................118N156N Disintegration...............................................5min4min Friability......................................................<0.1%<0.1% Dissolution（10min）........................................45%55% （20min）.......................................82%90% （30min）.......................................90%98%