Alpha-MethyldopaTablets （500mg）,Wg 1.Formulations No.1No.2 I.Alpha-Methyldopa........................................500g500g Lacto semonohydrate[8]..............................200g– Cornstarch[3]....................................................–200g
II.Kollidon30[1]................................................30g– Kollidon90F[1]..................................................–10g Isopropanol..................................................35mlq.s. III.KollidonCL....................................................20g15g Talc[10]..............................................................–8g Aerosil200[4]..................................................5g2g Magnesiumstearate[2]....................................8g– Calciumarachinate[2].........................................–2g 2.Manufacturing（Wetgranulation） GranulatethemixtureIwithsolutionII,pass througha0.8mmsieve,mix withIIIandpresswithlow/mediumcompressionforce. 3.Tabletproperties No.1No.2 Weight......................................................790mg696mg Diameter....................................................12mml2mm Form........................................................biplanarbiplanar Hardness......................................................80N95N Disintegration...............................................5min4min Friability.......................................................0.5%0.98%4. RemarkFor the production of tables cores for coating purposes the oblong formwould be better.
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