Vitamin B Complex Tablets, I

VitaminBComplexTablets,I
1.Formulations
No.1No.2
Thiaminemononitrate（BASF）..........................25g—
Thiaminehydrochloride（BASF）...........................—25g Riboflavin（BASF）............................................25g25g Nicotinamide.................................................80g80g CalciumD-panto thenate（BASF）......................40g40g Pyridoxinehydrochloride（BASF）......................16g16g Cyanocobalamingelatincoated0.1%（BASF）...16g16g AvicelpH101[5]..........................................282g282g Kollidon30[1]................................................16g16g Aerosil200[4]..................................................3g3g 2.Manufacturing（Directcompression）
Passallcomponentthrougha0.8mmsieve,mixandpresswithmedium
to highcompressionforce.
3.Tabletproperties
No.1No.2
Weight......................................................513mg504mg Diameter....................................................12mml2mm
Form........................................................biplanarbiplanar
Hardness.......................................................73N68N
Disintegration.............................................<1min<1min
Friability.......................................................0.4%0.8%
4. Chemical stability of vitamin B1 （40 C, closed）
0 Month 6 Months 12 Months
Formulation No. 1 100% 83% 72%
Formulation No. 2 100% 32% 11%
Result: Thiamine hydrochloride is not suitable in this formulations.