(1,200i.u. 60mg 30mg)
1.Formulations
No.1No.2
VitaminAacetatedrypowder........................2.4g2.4g 500000i.u./g(BASF)
Ascorbicacid,powder(BASF)......................60.0g60.0g VitaminEacetatedrypowder50%..............60.0g60.0g Mannito l.............................................................–100.0g Lacto semonohydrate[8]...........................105,0g–
AvicelpH101[5].........................................30.0g30.0g Kollidon25[1].............................................20.0g–
KollidonVA64[1]................................................–20.0g KollidonCL[1]....................................................–5.0g Talc[10]........................................................5.0g5.0g Aerosil200[4]...............................................1.0g1.0g 2.Manufacturing(Directcompression)
Passallcomponentsthrougha0.8mmsieve,mixandpresswith
mediumcompressionforce.
3.Tabletproperties
No.1No.2
Weight......................................................285mg279mg Diameter......................................................8mm8mm
Form........................................................biplanarbiplanar
Hardness......................................................53N67N
Disintegration.............................................15min6min
Friability.....................................................<0.1%<0.1%
关键字:vitamin