Vitamin C Chewable Tablets with Dextrose

VitaminC（Ascorbicacid）ChewableTablets withDextrose （100mg） 1.Formulations No.1No.2 I.Ascorbicacid,crystalline..............................105g— Ascorbicacid,ECcoated97.5%（Merck）..............–110g Dextrose......................................................500g500g II.Kollidon90F[1]...............................................4g4g Waterand/orisopropanol.........................30–50g30–50g III.Polyethyleneglycol6000,powder[6]................6g6g 2.Manufacturing（Wetgranulation） GranulatemixtureIwithsolutionII（inafluidizedbed）,sieve,addIIIand presswithhighcompressionforce. 3.Tabletproperties No.1No.2 Weight......................................................620mg620mg Diameter....................................................12mml2mm Form........................................................biplanarbiplanar Hardness.....................................................150N>100N Disintegration.............................................10minnottested Friability.....................................................<0.1%0.1%4. Chemical stability （40 C, closed）0 Months 3 Months 6 MonthsFormulation No. 1 100% 100% 100%Formulation No. 2 100% 92% 93%5. Remarks1. If no fluidized bed is available water should be avoided as granulationsolvent.2. The use of coated ascorbic acid does not increase the stability.