VitaminC VitaminELozenges (100mg 50mg) 1.Formulation I.Ascorbicacid,crystalline(BASF)...................100g VitaminEacetatedrypowderSD50(BASF)..100g Dextrose......................................................400g Kollidon90F[1]...............................................4g
II.Isopropanol....................................................25g III.Polyethyleneglycol6000,powder[6]................6g 2.Manufacturing(Wetgranulation) GranulatemixtureIwithisopropanol,dry,pass througha0.8mmsieve, mixwithIIIandpresswithhighcompressionforce. 3.Tabletproperties Weight......................................................600mg Diameter....................................................12mm Form........................................................biplanar Hardness......................................................61N Friability.....................................................<0.1% 4.Stabilityofappearance Nochangeofthetabletcolourduring3monthsat30Cand70% relativehumidity.
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