Vitamin B1 Vitamin B2 Vitamin B3 Vitamin B6 Injectable Solution

VitaminB1 VitaminB2 VitaminB3 VitaminB6Injectable Solution （100mg 6mg 40mg 4mg/2ml） 1.Formulation I.Thiaminehydrochloride（BASF）................11.0g Riboflavin-5’-phosphate,sodium...............6.6g Nicotinamide..........................................44.0g Pyridoxinehydrochloride（BASF）................4.4g II.Parabene.................................................1.8g Citricacid..............................................25.2g SodiumhydroxideSolution ,1molar........240ml Hydrochloricacid,0.1molar...................800ml WaterforInjectable s..............................960ml 2.Manufacturing PrepareSolution IIbyheatingandallowto coolbeforedissolvingthe componentsofIinit.Flush5–10min.withnitrogen ,filterthrougha 0.22μmmembraneandfillinto 2-mlampoulesundernitrogen . 3.PropertiesoftheSolution AclearyellowSolution wasobtainedhavingapHofaabout4.0. 4.Chemicalstability（20–25C） VitaminContentafter1year（HPLC） B193% B290% B3100% B697% VitaminB12wasnotstableinthisformulation