VitaminC CalciumCarbonate EffervescentTablets （500mg 300mg） 1.Formulation I.Calciumcarbonate.......................................315g Sodiumbicarbonate.....................................450g Tartaricacid,powder....................................600g Kollidon30[1]................................................35g
II.Kollidon30[1]................................................10g Isopropanol..................................................200g III.Sucrosecrystalline.......................................400g
IV.Ascorbicacid,crystalline（BASF）...................550g KollidonCL[1]..............................................120g Polyethyleneglycol6000,powder[6]..............60g 2.Manufacturing（Wetgranulation） GranulatemixtureIwithsolutionII,mixwithIIIanddry.AddIVandpress withahighcompressionforceatmaximum30%ofrelativeatmospheric humidity. 3.Tabletproperties Weight...................................................2,500mg Diameter....................................................20mm Form........................................................biplanar Hardness.....................................................100N Disintegration...............................................2min Friability..........................................................2%
关键字：vitamin calcium carbonate
