VitaminC（Ascorbicacid）ChewableTablets
（100mg,500mg,1000mg）
1.Formulation
Ascorbicacid,powder（BASF）.....................42.2%
Microcristallinecellulose,.............................28.3%
e.g.AvicelpH101[5]
Sucrose,powder........................................13.0%
Sucrose,crystalline.......................................8.0%
KollidonVA64[1].........................................2.4%
Cyclamatesodium........................................2.4%
Polyethyleneglycol6000,powder[6].............2.0%
Orangeflavour strawberryflavour（2 1）.......1.2%
Aerosil200[4]..............................................0.2%
Saccharinsodium.........................................0.1%
2.Manufacturing（Directcompression）
Mixallcomponents,pass througha0.8mmsieveandpressto tablets
withmediumto highcompressionforce.
3.Tabletproperties
VitaminCcontent/Tablet
100mg500mg1000mg Weight250mg1250mg2500mg Diameter8mml5mm20mm
Formbiplanarbiplanarbiplanar
Hardness157N>100N>150N
Disintegration（water）15min>15min14min
Friability<0.1%0.8%0.6%
4.Remark
Thisformulationalsoismentionedin“StandardzulassungenfrFertigarzneimittel”,
DeutscherApothekerverlag,1988.
关键字：vitamin chewable tablets
