VitaminA VitaminD3Concentrate, Water-miscible (120000i.u.A 12000i.u.D/g) (100000i.u.A 20000i.u.D/ml) 1.Formulations No.1No.2 120000i.u.A 100000i.u.A 12000i.u.D/g20000i.u.D/ml I.VitaminApalmitate............................7.10g6.5g 1.7Mioi.u./g(BASF) VitaminD340Mioi.u./g.....................0.03g55mg Butylhydroxyto luene...........................0.15g0.3g CremophorRH40[1].........................25.0g26.0g
II.Preservative..........................................q.s.q.s. Water.........................................ad100.0g67.2g 2.Manufacturing HeatthemixtureIto about65C,addveryslowlythewarmsolutionII (65C),withvigorousstirring. 3.Propertiesofthesolutions FormulationNo.1 Slightlyopalescent,yellowliquid,misciblewithwater(Clarity:34FTU). FormulationNo.2 Clarity:Clear(27FTU) Density(25C):1.014g/ml Viscosity(25C):25mPas Theconcentrateismisciblewithwaterandcanbeprocessedfurtherto liquidpharmaceuticals.
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