VitaminBComplex VitaminCSyrup,II 1.Formulation I.Thiaminehydrochloride(BASF)................27mg Riboflavinphosphatesodium..................27mg Nicotinamide........................................125mg Dexpanthenol(BASF)..............................55mg Pyridoxinehydrochloride(BASF)..............27mg Ascorbicacid,crystalline(BASF)............400mg Orangearoma........................................50mg EDTAsodium..........................................10mg
II.Propyleneglycol[1]...................................30g water(2 1) III.Parabene.............................................250mg Sorbito l,crystalline[10]..............................15g Sucrose,crystalline..................................100g Water........................................................70g to talamount...........................................216g 2.Manufacturing DissolvethecomponentsIinmixture
II.PreparesolutionIIIbyheating, coolandmixwithsolutionI/
II.Adjustto pH4,2–4,5.Usenitrogen as inertgasduringpackaging. 3.Propertiesofthesolution Yellowcleartastefullsolutionhavingadensityof1.23g/ml(25C).4. Chemical stability (20–25 C, dark)The following vitamin contents were determined by HPLC.Vitamin 0 Months 6 Months 9 Months 12 MonthsB1 100% 85% 85% –B2 100% 91% 91% 87%Nicotinamide 100% 100% 100% 100%Dexpanthenol 100% 88% 86% 86%B6 100% 100% 96% 96%C 100% 89% – 88%
关键字:vitamin complex